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WK1 Discussion - Week 1 dp Advanced Pathophysiology (Walden University).

MAIN POST – CYSTIC FIBROSIS Pathophysiology and Genetic Factor Cystic fibrosis (CF) is mainly caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The... channel transports negatively charged particles called chloride ions into and out of cells. Extracellular Level Changes with Cystic Fibrosis References Critical Care of the Adult Patient With Cystic Fibrosis King, Christopher S. et al. CHEST, Volume 155, Issue 1, 202 – 214 Mikesell, H. F. . M. (2019). Cystic fibrosis and genetics. Salem Press Encyclopedia of Health. Retrieved from direct=true&db=ers&AN=94416438&site=eds-live&scope=site Peters, S. (2014). Cystic fibrosis: a review of pathophysiology and current treatment recommendations. South Dakota Medicine: The Journal Of The South Dakota State Medical Association, 67(4), 148. Retrieved from direct=true&db=mnh&AN=24791377&site=eds-live&scope=site Walker, S. (2017). Optimizing Treatment Strategies to Improve Outcomes in the Management of Cystic Fibrosis. Journal of Managed Care Medicine, 20(1), 35. Retrieved from https://search- direct=true&db=edb&AN=124508827&site=eds-live&scope=site Cystic Fibrosis Etiology Cystic fibrosis (mucoviscidosis) is an autosomal-recessive disorder of the exocrine glands. Pathogenesis Cystic fibrosis is classified as an autosomal-recessive disorder. Clinical Manifestations Typical findings include a history of cough in a young adult or child; thick, tenacious sputum; recurrent pulmonary infections (commonly Pseudomonas aeruginosa); Diagnosis The diagnosis of cystic fibrosis is based on clinical and laboratory findings. Diagnostic studies that are routinely performed include ABG measurements Treatment Management of cystic fibrosis involves an interdisciplinary approach. A comprehensive program that focuses on multiorgan derangements is recommended. ::::::::::::::::::::::::::::::::::::::::CONTENT CONTINUED IN THE ATTACHMENT::::::::::::::::::::::::::::::::::::::::::::::::::: [Show More]

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